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    Spike Protein

    What studies show about SARS-CoV-2 spike protein persistence, amyloid formation and its effects on clotting and the brain.

    Start with these guides

    Illustration of SARS-CoV-2 spike protein fragments assembling into amyloid fibrils tangled in a fibrin clot
    Research
    Preclinical

    Spike Protein Amyloid Fibrils: How Spike685 Makes Clots Resist Lysis

    How spike protein amyloid fibrils change fibrin clots: what the 2025 Linköping study found for Spike601 and Spike685, and what it cannot yet tell us.

    Tim OttowitzApr 16, 2026
    6m
    Illustration of Thioflavin T fluorescence, with amyloid fibrils glowing against a dark microscope background
    Guide

    Amyloid Fibril Test: Methods Used to Detect Amyloid Fibrils

    How an amyloid fibril test works: Thioflavin T, Congo red, electron microscopy, X-ray diffraction and seeding assays compared, with which are clinical.

    Tim OttowitzOct 15, 2026
    11m

    All spike protein articles

    3D medical illustration of a lipid nanoparticle interacting with a cellular phospholipid bilayer, disrupting membrane signaling
    Research
    Review

    Lipid Nanoparticle Membrane Dysfunction: What the Omics Data Show

    A plain-English guide to lipid nanoparticle membrane dysfunction, explaining how ionizable lipids alter cell signaling, metabolism, and membranes.

    Tim OttowitzOct 24, 2026
    9m
    3D medical visualization of lipid nanoparticles carrying mRNA through a heart capillary, docking with endothelial lining cells
    Research
    Preclinical

    Lipid Nanoparticle Biodistribution: Where mRNA Goes in the Body

    A plain-English guide to lipid nanoparticle biodistribution research, showing how whole-body imaging tracks mRNA delivery to heart capillaries.

    Tim OttowitzOct 19, 2026
    11m
    Microscopic illustration of spike protein inducing amyloid fibril aggregation
    Guide
    Clinical Trial

    Spike Protein Test: Antibody, Antigen, and Downstream Testing

    Learn how spike protein tests work. Why antibody assays measure memory rather than active protein, and how downstream amyloid testing reveals microclots.

    Tim OttowitzOct 19, 2026
    6m
    Illustration of SARS-CoV-2 spike protein fragments assembling into amyloid fibrils
    Guide

    Post-Vaccination Syndrome: Symptoms, Duration and the Spike Research

    Post-vaccination syndrome symptoms, how long it can last, and what spike persistence, spike amyloid fibrils and microclot studies show about the cause.

    Tim OttowitzOct 16, 2026
    6m
    Abstract illustration of pale blue branching fibrils against a light background
    Research
    Review

    COVID Vaccine Harms: What the 2025 JPandS Review Argues

    A plain-language walkthrough of the 2025 JPandS review on COVID vaccine harms: what it claims, which sources hold up, and where the evidence is weak.

    Tim OttowitzSep 22, 2026
    9m
    Illustration of spike protein fragments stacking into beta-sheet amyloid fibrils
    Research
    Review

    Is Spike Protein a Prion? What a 2026 Prion-Like Domain Review Shows

    Is spike protein a prion? A 2026 review links spike prion-like domains to amyloid-beta and tau cross-seeding. Here's what's proven and what isn't yet.

    Tim OttowitzSep 12, 2026
    10m
    Caucasian clinical scientist reviewing cellular viral samples under a fluorescence research microscope
    Research
    Preclinical

    SARS-CoV-2 Cell-to-Cell Spread: Nanotubes, Syncytia and Vesicles

    How might SARS-CoV-2 spread from cell to cell without leaving? A simple guide to the nanotubes, fused cells and vesicles seen in a 2022 microscopy study.

    Tim OttowitzAug 31, 2026
    7m
    Microscopy-style illustration of branched amyloid fibrils forming from cleaved spike protein fragments
    Research
    Preclinical

    Neutrophil Elastase and Spike Protein: How Amyloid Forms

    Neutrophil elastase cuts SARS-CoV-2 spike into amyloid-forming fragments. A plain-English walkthrough of the 2022 JACS study and what it does not show.

    Tim OttowitzMay 4, 2026
    7m
    Female clinical biochemist inspecting blood plasma sample vials for mass spectrometry analysis in an analytical laboratory
    Resource
    Observational

    Spike Protein Antibody vs Antigen Testing: What Each One Measures

    Spike antibody tests measure immune memory, not spike protein. What antigen testing adds, why detox protocols stall, and what a serious panel includes.

    Tim OttowitzApr 30, 2026
    9m
    Illustration of SARS-CoV-2 spike protein fragments assembling into amyloid fibrils
    Research
    Preclinical

    Spike Protein and Alzheimer's: The Spike Amyloid Cross-Seeding Study

    Spike protein amyloid sped up misfolding of Alzheimer's amyloid-beta and prion protein in a lab study. What it shows about the brain, and what it doesn't.

    Tim OttowitzApr 30, 2026
    12m
    Fluorescence microscopy style illustration of amyloid-positive microclot deposits in plasma
    Research
    Review

    Post-Vaccination Microclots: What the Spike-Fibrin Research Shows

    What research says about microclots after mRNA vaccination: the shared spike sequence argument, the PV/PIS cohort findings, and where the evidence stops.

    Tim OttowitzApr 22, 2026
    9m
    Illustration of stacked amyloid fibers forming a cross-beta structure
    Research
    Preclinical

    Amyloid-Beta Antimicrobial Peptide: Amyloid as an Immune Defense

    Is amyloid-beta an antimicrobial peptide? How amyloid works as immune defense, what Meytal Landau's lab showed, and where spike protein fits in.

    Tim OttowitzApr 19, 2026
    8m
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